Maelstrom, aDrosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage
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چکیده
منابع مشابه
Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster.
The nuage is an electron-dense perinuclear structure that is known to be a hallmark of animal germ-line cells. Although the conservation of the nuage throughout evolution accentuates its essentiality, its role(s) and the exact mechanism(s) by which it functions in the germ line still remain unknown. Here, we report a nuage component, Krimper (KRIMP), in Drosophila melanogaster and show that it ...
متن کاملThe Drosophila bifocal gene encodes a novel protein which colocalizes with actin and is necessary for photoreceptor morphogenesis.
Photoreceptor cells of the Drosophila compound eye begin to develop specialized membrane foldings at the apical surface in midpupation. The microvillar structure ultimately forms the rhabdomere, an actin-rich light-gathering organelle with a characteristic shape and morphology. In a P-element transposition screen, we isolated mutations in a gene, bifocal (bif), which is required for the develop...
متن کاملDrosophila valois encodes a divergent WD protein that is required for Vasa localization and Oskar protein accumulation.
valois (vls) was identified as a posterior group gene in the initial screens for Drosophila maternal-effect lethal mutations. Despite its early genetic identification, it has not been characterized at the molecular level until now. We show that vls encodes a divergent WD domain protein and that the three available EMS-induced point mutations cause premature stop codons in the vls ORF. We have g...
متن کاملRepression of Retroelements in Drosophila Germline via piRNA Pathway by the Tudor Domain Protein Tejas
The Piwi-interacting RNAs (piRNAs) have been shown to safeguard the animal germline genome against deleterious retroelements [1-9]. Many factors involved in the production of piRNAs localize to nuage, a unique perinuclear structure in animal germline cells [10], suggesting that nuage may function as a site for processing of germline piRNAs [1, 3-6, 11-14]. Here we report a conserved yet unchara...
متن کاملLive imaging of nuage and polar granules: evidence against a precursor-product relationship and a novel role for Oskar in stabilization of polar granule components.
Nuage, a germ line specific organelle, is remarkably conserved between species, suggesting that it has an important germline cell function. Very little is known about the specific role of this organelle, but in Drosophila three nuage components have been identified, the Vasa, Tudor and Aubergine proteins. Each of these components is also present in polar granules, structures that are assembled ...
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ژورنال
عنوان ژورنال: Development
سال: 2003
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.00310